abstract：:This study tested the use of a subject-own-control, multiple crossover design for evaluating the clinical effects of an established tricyclic antidepressant drug, imipramine. Although significant physiological and cognitive performance effects were demonstrated, only one clinical measure, target symptom change rated b...

journal_title：Journal of affective disorders

authors： Glass RM,Uhlenhuth EH,Matuzas W,McCracken S,Greene S

更新日期：1982-12-01 00:00:00

abstract：:Erythrocyte/plasma lithium ratios were determined in 41 polar manic depressive outpatients maintained on lithium for a mean of 64 months. Sixteen patients experienced affective episodes requiring additional pharmacologic intervention during periods when their plasma lithium averaged 0.7 meq/l or above for at least 3 p...

journal_title：Journal of affective disorders

authors： Kocsis JH,Kantor JS,Lieberman KW,Stokes PE

更新日期：1982-09-01 00:00:00

abstract：:One explanation for the association between mitral valve prolapse (MVP) and panic attacks in clinic populations is that panic attacks represent a set of symptoms caused by mitral prolapse. Since mitral prolapse is often familial, this hypothesis predicts a higher incidence of panic attacks in relatives of persons with...

journal_title：Journal of affective disorders

authors： Crowe RR,Gaffney G,Kerber R

更新日期：1982-06-01 00:00:00

abstract：:Endogenously depressed in-patients were treated for four weeks with either lithium + L-tryptophan (N = 22) or amitriptyline (N = 21) in an open study. Before and weekly during treatment the patients were evaluated by means of Hamilton rating scale, and blood samples were collected for determination of serum concentrat...

journal_title：Journal of affective disorders

authors： Honoré P,Møller SE,Jørgensen A

更新日期：1982-03-01 00:00:00

abstract：:Plasma levels of gamma-aminobutyric acid (GABA) were determined in 34 clinically symptomatic patients with diagnosis of affective disorder and in 20 normal controls. Lowest levels were found in patients with familial pure depressive disease and in depression spectrum disease, while levels of patients with sporadic dep...

journal_title：Journal of affective disorders

authors： Petty F,Schlesser MA

更新日期：1981-12-01 00:00:00

abstract：:This study was performed on 65 depressed in-patients who were included in previously reported trials of imipramine and clomipramine. Before and during treatment, blood samples were collected for estimation of the availability of tryptophan and tyrosine by measurement of their plasma ratios to competing amino acids, an...

journal_title：Journal of affective disorders

authors： Møller SE,Reisby N,Ortmann J,Elley J,Krautwald O

更新日期：1981-09-01 00:00:00

abstract：:Assortative mating was determined in 170 spouses of patients with major affective illness (bipolar and unipolar). An increase in affective disorders was found in both wives of affected men and husbands of affected women. The data suggest that assortative mating is present in the familial transmission of affective diso...

journal_title：Journal of affective disorders

authors： Baron M,Mendlewicz J,Gruen R,Asnis L,Fieve RR

更新日期：1981-06-01 00:00:00

abstract：:The plasma prolactin response to thyrotropin-releasing hormone, which is thought to be mediated by central 5-HT mechanisms, has been studied in patients with affective disorders. There was no difference between depressive patients (taken as a whole), bipolar patients undergoing a manic phase and controls in the prolac...

journal_title：Journal of affective disorders

authors： Coppen A,Rao VA,Bishop M,Abou-Saleh MT,Wood K

更新日期：1980-12-01 00:00:00

abstract：:The outcome of antidepressant drug treatment was measured in 200 patients, 145 seen in psychiatric out-patient clinics and 55 in general practice, after 4 weeks of therapy. The results of the 200 patients taken together suggested that prognosis was largely determined by factors dependent on the natural history of the ...

journal_title：Journal of affective disorders

authors： Tyrer PJ,Lee I,Edwards JG,Steinberg B,Elliott EJ,Nightingale JH

更新日期：1980-09-01 00:00:00

abstract：:The ratio of the plasma of total tryptophan to those amino acids that compete with tryptophan during transport into the brain was determined in 60 control subjects and 87 patients suffering from endogenous depression, all females. The plasma ratio in the control subjects showed a significant negative correlation with ...

journal_title：Journal of affective disorders

authors： Møller SE,Kirk L,Honoré P

更新日期：1980-03-01 00:00:00

abstract：:The Slater computational model for use in distinguishing between polygenic inheritance and the effects of a single dominant gene with incomplete penetrance was applied to 15 kindreds of anxiety neurosis (panic disorder). The number of observed unilateral pairs (two ancestral cases from one side of the kindred) was sig...

journal_title：Journal of affective disorders

authors： Pauls DL,Crowe RR,Noyes R Jr

更新日期：1979-12-01 00:00:00

abstract：:Narrow definitions of schizophrenia increase homogeneity at the expense of leaving unclassified many patients with shizophrenic symptoms. Family history and follow-up studies indicate that many such patients ought to be classified with those having affective disorders. This study determines morbid risks for affective ...

journal_title：Journal of affective disorders

authors： Coryell W,Tsuang MT

更新日期：1979-03-01 00:00:00